Abstract
The Hedgehog signaling pathway plays a crucial role in development and disease. Its putative origins in an ancient system involved in regulating bacterial lipid transport and homeostasis offers clues about how the pathway might work today.
MeSH terms
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Amino Acid Sequence
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Animals
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Evolution, Molecular
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Hedgehog Proteins / classification
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Hedgehog Proteins / genetics
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Hedgehog Proteins / metabolism*
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Humans
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Models, Biological
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Molecular Sequence Data
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Patched Receptors
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Phylogeny
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Protein Binding
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Receptors, Cell Surface / genetics
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Receptors, Cell Surface / metabolism
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Receptors, G-Protein-Coupled / genetics
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Receptors, G-Protein-Coupled / metabolism
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Sequence Homology, Amino Acid
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Signal Transduction*
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Smoothened Receptor
Substances
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Hedgehog Proteins
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Patched Receptors
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Receptors, Cell Surface
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Receptors, G-Protein-Coupled
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SMO protein, human
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Smoothened Receptor