Small molecule inhibitors of the PI3-kinase family

Curr Top Microbiol Immunol. 2010:347:263-78. doi: 10.1007/82_2010_44.

Abstract

The PI3-K family is one of the most intensely pursued classes of drug targets. This chapter reviews some of the chemical and structural features that determine the selectivity of PI3-K inhibitors, by focusing on a few key compounds that have been instrumental in guiding our understanding of how to design drugs against this family.

Publication types

  • Review

MeSH terms

  • Adenine / analogs & derivatives
  • Adenine / pharmacology
  • Androstadienes / pharmacology
  • Animals
  • Ataxia Telangiectasia Mutated Proteins
  • Cell Cycle Proteins / antagonists & inhibitors
  • Chromones / pharmacology
  • DNA-Activated Protein Kinase
  • DNA-Binding Proteins / antagonists & inhibitors
  • Humans
  • Morpholines / pharmacology
  • Neoplasms / drug therapy
  • Nuclear Proteins
  • Phosphoinositide-3 Kinase Inhibitors*
  • Protein Kinase Inhibitors / pharmacology*
  • Protein Serine-Threonine Kinases / antagonists & inhibitors
  • Quinazolines / pharmacology
  • Tumor Suppressor Proteins / antagonists & inhibitors
  • Wortmannin

Substances

  • Androstadienes
  • Cell Cycle Proteins
  • Chromones
  • DNA-Binding Proteins
  • IC 87114
  • Morpholines
  • Nuclear Proteins
  • Phosphoinositide-3 Kinase Inhibitors
  • Protein Kinase Inhibitors
  • Quinazolines
  • Tumor Suppressor Proteins
  • 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one
  • ATM protein, human
  • Ataxia Telangiectasia Mutated Proteins
  • Atm protein, mouse
  • DNA-Activated Protein Kinase
  • Prkdc protein, mouse
  • Protein Serine-Threonine Kinases
  • Adenine
  • Wortmannin