Abstract
The hepatic peptide hormone hepcidin is the principal regulator of iron absorption and its tissue distribution. Pathologically increased hepcidin concentrations cause or contribute to iron-restrictive anemias including anemias associated with inflammation, chronic kidney disease and some cancers. Hepcidin deficiency results in iron overload in hereditary hemochromatosis and ineffective erythropoiesis. The hepcidin-ferroportin axis is the principal regulator of extracellular iron homeostasis in health and disease, and is a promising target for the diagnosis and treatment of iron disorders and anemias.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Aging / metabolism
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Anemia / metabolism
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Animals
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Antimicrobial Cationic Peptides / agonists
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Antimicrobial Cationic Peptides / antagonists & inhibitors
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Antimicrobial Cationic Peptides / metabolism*
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Cation Transport Proteins / metabolism
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Female
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Hepatocytes / metabolism
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Hepcidins
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Humans
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Inflammation / metabolism
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Interleukin-6 / metabolism
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Iron / metabolism*
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Iron Metabolism Disorders / drug therapy
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Iron Metabolism Disorders / metabolism*
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Iron, Dietary / metabolism
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Kidney Diseases / metabolism
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Male
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Mice
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Neoplasms / metabolism
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Transferrin / metabolism
Substances
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Antimicrobial Cationic Peptides
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Cation Transport Proteins
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HAMP protein, human
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Hamp protein, mouse
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Hepcidins
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Interleukin-6
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Iron, Dietary
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Transferrin
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metal transporting protein 1
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Iron