6beta-[N,N-Bis(2-chloroethyl)amino]-17-(cyclopropylmethyl)-4,5alpha-epoxy-3,14-dihydroxymorphinan(chlornaltrexamine) a potent opioid receptor alkylating agent with ultralong narcotic antagonist actitivty

J Med Chem. 1978 Jul;21(7):598-9. doi: 10.1021/jm00205a002.
No abstract available

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Alkylating Agents / chemical synthesis*
  • Alkylating Agents / pharmacology
  • Analgesia
  • Binding, Competitive
  • Morphine / antagonists & inhibitors
  • Naloxone / analogs & derivatives*
  • Naltrexone / analogs & derivatives*
  • Naltrexone / chemical synthesis
  • Naltrexone / pharmacology
  • Narcotic Antagonists / chemical synthesis*
  • Nitrogen Mustard Compounds / chemical synthesis
  • Nitrogen Mustard Compounds / pharmacology
  • Receptors, Opioid / drug effects*

Substances

  • Alkylating Agents
  • Narcotic Antagonists
  • Nitrogen Mustard Compounds
  • Receptors, Opioid
  • Naloxone
  • Naltrexone
  • chlornaltrexamine
  • Morphine