G-protein-mediated regulation of phospholipase C Involvement of βγ subunits

J Boyer; A Paterson; T K Harden

doi:10.1016/1050-1738(94)90015-9

G-protein-mediated regulation of phospholipase C Involvement of βγ subunits

Trends Cardiovasc Med. 1994 Mar-Apr;4(2):88-95. doi: 10.1016/1050-1738(94)90015-9.

Authors

J Boyer¹, A Paterson, T K Harden

Affiliation

¹ Department of Pharmacology, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.

PMID: 21244901
DOI: 10.1016/1050-1738(94)90015-9

Abstract

The protein components of the G-protein-linked cell surface receptor-regulated inositol lipid-signaling cascade have been identified recently. The G(q) family of G-protein α subunits is responsible for pertussis toxin-insensitive activation of a family of phospholipase C-β isoenzymes. However, it also has been shown that G-protein βγ subunits activate certain of these phospholipase C-β isoenzymes, and that this novel activity may account for activation of phospholipase C by G proteins that are not members of the G(q) family, including those that account for pertussis-toxin-sensitive inositol lipid signaling.