Abstract
The complete amino acid sequence of the receptor for organic calcium channel blockers (CaCB) from rabbit lung has been deduced by cloning and sequence analysis of the cDNA. Synthetic RNA derived from this cDNA induces the formation of a functional CaCB-sensitive high voltage activated calcium channel in Xenopus oocytes.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Base Sequence
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Calcium Channels / metabolism
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Calcium Channels / physiology*
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Cell Membrane / physiology
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Cell Membrane / ultrastructure
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Cloning, Molecular
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Electric Stimulation
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Female
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Gene Expression
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Lung / metabolism
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Lung / physiology*
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Membrane Potentials
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Membrane Proteins / genetics*
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Membrane Proteins / physiology
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Models, Structural
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Molecular Sequence Data
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Oocytes / physiology
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Protein Conformation
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RNA, Messenger / genetics
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Rabbits
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Receptors, Nicotinic / genetics
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Receptors, Nicotinic / physiology*
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Xenopus laevis
Substances
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Calcium Channels
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Membrane Proteins
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RNA, Messenger
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Receptors, Nicotinic