Abstract
Recent studies have indicated that eukaryotic cells contain proteins that are post-translationally modified by long-chain, thioether-linked prenyl groups. These proteins include yeast mating factors, ras proteins and nuclear lamins. The modification occurs on a cysteine residue near the C terminus and appears to initiate a set of additional protein modification reactions that promote attachment of the proteins to specific membranes.
MeSH terms
-
Animals
-
Cell Membrane / metabolism*
-
Cells / metabolism*
-
Eukaryotic Cells / metabolism*
-
Humans
-
Lamins
-
Mating Factor
-
Nuclear Proteins / metabolism
-
Peptides / metabolism
-
Polyisoprenyl Phosphates / metabolism*
-
Protein Processing, Post-Translational
-
Proteins / metabolism*
-
Proto-Oncogene Proteins / metabolism
-
Proto-Oncogene Proteins p21(ras)
Substances
-
Lamins
-
Nuclear Proteins
-
Peptides
-
Polyisoprenyl Phosphates
-
Proteins
-
Proto-Oncogene Proteins
-
Mating Factor
-
HRAS protein, human
-
Proto-Oncogene Proteins p21(ras)