Prenyl proteins in eukaryotic cells: a new type of membrane anchor

Trends Biochem Sci. 1990 Apr;15(4):139-42. doi: 10.1016/0968-0004(90)90213-u.

Abstract

Recent studies have indicated that eukaryotic cells contain proteins that are post-translationally modified by long-chain, thioether-linked prenyl groups. These proteins include yeast mating factors, ras proteins and nuclear lamins. The modification occurs on a cysteine residue near the C terminus and appears to initiate a set of additional protein modification reactions that promote attachment of the proteins to specific membranes.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Membrane / metabolism*
  • Cells / metabolism*
  • Eukaryotic Cells / metabolism*
  • Humans
  • Lamins
  • Mating Factor
  • Nuclear Proteins / metabolism
  • Peptides / metabolism
  • Polyisoprenyl Phosphates / metabolism*
  • Protein Processing, Post-Translational
  • Proteins / metabolism*
  • Proto-Oncogene Proteins / metabolism
  • Proto-Oncogene Proteins p21(ras)

Substances

  • Lamins
  • Nuclear Proteins
  • Peptides
  • Polyisoprenyl Phosphates
  • Proteins
  • Proto-Oncogene Proteins
  • Mating Factor
  • HRAS protein, human
  • Proto-Oncogene Proteins p21(ras)