Allosteric modulation of seven transmembrane spanning receptors: theory, practice, and opportunities for central nervous system drug discovery

J Med Chem. 2012 Feb 23;55(4):1445-64. doi: 10.1021/jm201139r. Epub 2012 Jan 6.
No abstract available

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Allosteric Regulation
  • Animals
  • Central Nervous System Agents / chemistry*
  • Central Nervous System Agents / pharmacology*
  • Drug Discovery
  • Humans
  • Ligands
  • Receptors, G-Protein-Coupled / agonists
  • Receptors, G-Protein-Coupled / antagonists & inhibitors
  • Receptors, G-Protein-Coupled / metabolism*
  • Receptors, Metabotropic Glutamate / metabolism
  • Receptors, Muscarinic / metabolism
  • Structure-Activity Relationship

Substances

  • Central Nervous System Agents
  • Ligands
  • Receptors, G-Protein-Coupled
  • Receptors, Metabotropic Glutamate
  • Receptors, Muscarinic