Abstract
There is accumulating evidence that aggregating, misfolded proteins may have an impact on autophagic function, suggesting that this could be a secondary pathological mechanism in many diseases. In this review, we focus on the role of autophagy in four major neurodegenerative diseases: Alzheimer disease (AD), Huntington's disease (HD), Parkinson's disease (PD) and amyotropic lateral sclerosis.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Autophagy / drug effects*
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Central Nervous System / drug effects
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Central Nervous System / metabolism
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Central Nervous System / pathology*
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Disease Progression
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Humans
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Molecular Targeted Therapy / methods*
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Neurodegenerative Diseases / drug therapy*
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Neurodegenerative Diseases / metabolism
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Neurodegenerative Diseases / pathology*
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Signal Transduction / drug effects
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TOR Serine-Threonine Kinases / metabolism
Substances
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TOR Serine-Threonine Kinases