Abstract
Hydrogen peroxide and organic hydroperoxides react with haemoglobin to release iron which can be complexed to apotransferrin, bleomycin and desferrioxamine. This released iron promotes deoxyribose degradation by a Fenton reaction, DNA degradation in the presence of bleomycin and stimulates lipid peroxidation. It is likely that iron released from haemoglobin is the true generator of hydroxyl radicals in the Fenton reaction.
MeSH terms
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Apoproteins*
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Bleomycin / metabolism
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Catalase / pharmacology
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Ceruloplasmin / pharmacology
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Deferoxamine / pharmacology
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Deoxyribose / metabolism
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Hemoglobins / metabolism*
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Humans
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Hydrogen Peroxide / pharmacology
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Hydroxides / metabolism
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Hydroxyl Radical
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Iron / metabolism*
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Lipid Peroxides / metabolism*
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Peroxides / pharmacology*
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Transferrin / pharmacology
Substances
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Apoproteins
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Hemoglobins
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Hydroxides
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Lipid Peroxides
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Peroxides
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Transferrin
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apotransferrin
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Bleomycin
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Hydroxyl Radical
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Deoxyribose
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Hydrogen Peroxide
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Iron
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Catalase
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Ceruloplasmin
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Deferoxamine