Abstract
Biochemical and biophysical studies on Aplysia sensory neurons indicate that inhibitory responses to the molluscan peptide FMRFamide are mediated by lipoxygenase metabolites of arachidonic acid. These compounds are a new class of second messengers in neurons.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Aplysia / physiology*
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Arachidonic Acid
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Arachidonic Acids / metabolism*
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Arachidonic Acids / pharmacology
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Electrophysiology
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FMRFamide
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Hydroxy Acids / metabolism
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Hydroxyeicosatetraenoic Acids / physiology
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Ion Channels / drug effects
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Ion Channels / physiology
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Leukotrienes*
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Lipoxygenase / metabolism*
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Neurons, Afferent / drug effects
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Neurons, Afferent / physiology*
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Neuropeptides / pharmacology
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Phospholipases / antagonists & inhibitors
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Synapses / physiology*
Substances
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Arachidonic Acids
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Hydroxy Acids
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Hydroxyeicosatetraenoic Acids
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Ion Channels
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Leukotrienes
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Neuropeptides
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Arachidonic Acid
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FMRFamide
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12-HPETE
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Lipoxygenase
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Phospholipases