Primary structure and functional expression of the inositol 1,4,5-trisphosphate-binding protein P400

Nature. 1989 Nov 2;342(6245):32-8. doi: 10.1038/342032a0.

Abstract

Cloning and expression of functional P400 protein from cerebellar Purkinje neurons shows that this protein is a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Antibodies, Monoclonal
  • Calcium Channels*
  • Cerebellum / metabolism
  • Cloning, Molecular
  • DNA / genetics*
  • DNA / isolation & purification
  • Gene Library
  • Genes
  • Inositol 1,4,5-Trisphosphate / metabolism*
  • Inositol 1,4,5-Trisphosphate Receptors
  • Mice
  • Molecular Sequence Data
  • Protein Conformation
  • Receptors, Cell Surface / biosynthesis
  • Receptors, Cell Surface / genetics*
  • Receptors, Cell Surface / metabolism
  • Receptors, Cholinergic / genetics
  • Receptors, Cytoplasmic and Nuclear*
  • Restriction Mapping
  • Ryanodine / metabolism
  • Ryanodine Receptor Calcium Release Channel
  • Sequence Homology, Nucleic Acid

Substances

  • Antibodies, Monoclonal
  • Calcium Channels
  • Inositol 1,4,5-Trisphosphate Receptors
  • Receptors, Cell Surface
  • Receptors, Cholinergic
  • Receptors, Cytoplasmic and Nuclear
  • Ryanodine Receptor Calcium Release Channel
  • Ryanodine
  • Inositol 1,4,5-Trisphosphate
  • DNA