Abstract
Quantitative autoradiographic distribution patterns of sigma/PCP and NMDA receptors show striking similarities but not in all brain areas. We have identified an endogenous ligand of brain PCP receptors which noncompetitively antagonizes NMDA-induced neurotransmitter release from brain slices. These data support the concept that the sigma/PCP receptor ligands may exert their unique behavioral effects by indirect modulation of NMDA-mediated transmission.
Publication types
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Acetylcholine / metabolism
-
Animals
-
Aspartic Acid / analogs & derivatives
-
Aspartic Acid / pharmacology
-
Brain / physiology*
-
Male
-
N-Methylaspartate
-
Norepinephrine / metabolism
-
Organ Specificity
-
Rats
-
Rats, Inbred Strains
-
Receptors, N-Methyl-D-Aspartate
-
Receptors, Neurotransmitter / drug effects
-
Receptors, Neurotransmitter / physiology*
-
Receptors, Opioid / drug effects
-
Receptors, Opioid / physiology*
-
Receptors, Phencyclidine
-
Receptors, sigma
Substances
-
Receptors, N-Methyl-D-Aspartate
-
Receptors, Neurotransmitter
-
Receptors, Opioid
-
Receptors, Phencyclidine
-
Receptors, sigma
-
Aspartic Acid
-
N-Methylaspartate
-
Acetylcholine
-
Norepinephrine