Abstract
We have deduced the entire 1,370-amino-acid sequence of the human insulin receptor precursor from a single complementary DNA clone. The precursor starts with a 27-amino-acid signal sequence, followed by the receptor alpha-subunit, a precursor processing enzyme cleavage site, then the beta-subunit containing a single 23-amino-acid transmembrane sequence. There are sequence homologies to human epidermal growth factor receptor and the members of the src family of oncogene products.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Base Sequence
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DNA / genetics
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ErbB Receptors
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Genes
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Humans
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Membrane Proteins / genetics
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Molecular Weight
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Oncogenes*
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Protein Conformation
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Protein Kinases / genetics*
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Protein-Tyrosine Kinases
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RNA, Messenger / genetics
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Receptor, Insulin* / genetics
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Receptors, Cell Surface / genetics
Substances
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Membrane Proteins
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RNA, Messenger
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Receptors, Cell Surface
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DNA
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Protein Kinases
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ErbB Receptors
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Protein-Tyrosine Kinases
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Receptor, Insulin