Studies with the neurotoxicant 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and several of its analogs

R E Heikkila; S K Youngster; D U Panek; A Giovanni; P K Sonsalla

doi:10.1016/0300-483x(88)90035-2

Studies with the neurotoxicant 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and several of its analogs

Toxicology. 1988 May;49(2-3):493-501. doi: 10.1016/0300-483x(88)90035-2.

Authors

R E Heikkila¹, S K Youngster, D U Panek, A Giovanni, P K Sonsalla

Affiliation

¹ Department of Neurology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway 08854.

PMID: 3259742
DOI: 10.1016/0300-483x(88)90035-2

Abstract

The nigrostriatal dopaminergic neurotoxicity of MPTP was prevented in mice in a dose-dependent manner by the monoamine oxidase-B (MAO-B) inhibitor deprenyl. This finding, combined with other observations, points out the important role of MAO-B in the bioactivation of MPTP. In the present study, some comparisons between MPTP and several of its structural analogs will be presented.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

MeSH terms

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
1-Methyl-4-phenylpyridinium
Animals
Dose-Response Relationship, Drug
Male
Mice
Monoamine Oxidase Inhibitors / pharmacology
Pyridines / toxicity*
Pyridinium Compounds / toxicity
Receptors, Dopamine / drug effects*
Structure-Activity Relationship

Substances

Monoamine Oxidase Inhibitors
Pyridines
Pyridinium Compounds
Receptors, Dopamine
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
1-Methyl-4-phenylpyridinium