Abstract
Ten novel derivatives of 11H-indeno [1,2-b] quinolin-11-one (1-10) were synthesized and pharmacologically screened. All compounds showed analgesic activity. Anti-inflammatory activity was found only for alkylamine derivatives 1-6. The most active 10-ethylamine derivative 2 showed also ulcerogenic properties. The LD50/UD50 and UD50/ED50 values for compound 2 were less satisfactory than those for ibuprofen.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis*
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Anti-Inflammatory Agents, Non-Steroidal / toxicity
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Chemical Phenomena
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Chemistry
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Indenes / chemical synthesis
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Indenes / pharmacology*
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Indenes / toxicity
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Lethal Dose 50
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Male
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Mice
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Quinolines / chemical synthesis
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Quinolines / pharmacology*
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Quinolines / toxicity
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Rats
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Rats, Inbred Strains
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Stomach Ulcer / chemically induced
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Indenes
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Quinolines