Acetaminophen-induced hepatic necrosis. V. Correlation of hepatic necrosis, covalent binding and glutathione depletion in hamsters

Pharmacology. 1974;12(3):129-43. doi: 10.1159/000136531.
No abstract available

MeSH terms

  • Acetaminophen / administration & dosage
  • Acetaminophen / blood
  • Acetaminophen / toxicity*
  • Animals
  • Chemical and Drug Induced Liver Injury / etiology*
  • Chemical and Drug Induced Liver Injury / metabolism
  • Chemical and Drug Induced Liver Injury / pathology
  • Cricetinae
  • Depression, Chemical
  • Glutathione / metabolism*
  • Lethal Dose 50
  • Liver / drug effects*
  • Liver / pathology
  • Liver / ultrastructure
  • Male
  • Methylcholanthrene / pharmacology
  • Microsomes, Liver / drug effects
  • Microsomes, Liver / metabolism
  • Necrosis / chemically induced
  • Phenobarbital / pharmacology
  • Piperonyl Butoxide / pharmacology
  • Protein Binding / drug effects
  • Rats
  • Stimulation, Chemical

Substances

  • Acetaminophen
  • Methylcholanthrene
  • Glutathione
  • Piperonyl Butoxide
  • Phenobarbital