Abstract
Ketoconazole at concentrations of 1-10 micrograms/ml dose dependently inhibits mitogen-induced blastogenesis, antibody-dependent and spontaneous cytotoxic (natural killer) activity of human lymphocytes and random migration of human leukocytes. Lectin-dependent cytotoxic activity is not affected by the drug.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antibody-Dependent Cell Cytotoxicity / drug effects*
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Cell Migration Inhibition
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Cells, Cultured
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Cytotoxicity Tests, Immunologic
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Humans
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Ketoconazole / pharmacology*
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Killer Cells, Natural / immunology*
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Leukocytes / immunology*
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Lymphocyte Activation / drug effects
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Lymphocytes / immunology*
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Phytohemagglutinins / pharmacology
Substances
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Phytohemagglutinins
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Ketoconazole