Abstract
Ca2+/C1- increases the L-[3H]glutamate binding to rat brain synaptic membranes. It was suggested that Ca2+/C1- expresses a new class of glutamate receptors. We report several lines of evidence suggesting that Ca2+/C1- in fact favours a glutamate transport into membrane vesicles. This finding may serve to reconcile most of the discrepancies found in the literature on the glutamate binding and its pharmacology.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Biological Transport / drug effects
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Brain / metabolism*
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Calcium / pharmacology*
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Chlorides / pharmacology*
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Glutamates / metabolism*
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Kinetics
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Male
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Osmolar Concentration
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Rats
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Rats, Inbred Strains
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Receptors, Glutamate
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Receptors, Neurotransmitter / drug effects
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Receptors, Neurotransmitter / metabolism*
Substances
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Chlorides
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Glutamates
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Receptors, Glutamate
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Receptors, Neurotransmitter
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Calcium