Abstract
AT-125, (alpha S, 5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid, at a concentration of 5 microM was found to inhibit the growth of human pancreatic carcinoma cells (MIA PaCa-2) by 78% after 72 hours in continuous culture. It was found that MIA PaCa-2 gamma-glutamyl transpeptidase (10 nmol/min/10(6) cells) was irreversibly inactivated by AT-125 with an inactivation half-life of 80 minutes at 450 microM.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Antibiotics, Antineoplastic / pharmacology*
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Cells, Cultured
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Glycine / analogs & derivatives*
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Glycine / pharmacology
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Half-Life
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Humans
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Isoxazoles / pharmacology*
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Oxazoles / pharmacology*
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Pancreatic Neoplasms / enzymology*
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Time Factors
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gamma-Glutamyltransferase / antagonists & inhibitors*
Substances
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Antibiotics, Antineoplastic
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Isoxazoles
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Oxazoles
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gamma-Glutamyltransferase
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acivicin
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Glycine