Abstract
Experiments on whole animals, guinea pig isolated ileum, individual neurones in situ and cultured neuroblastoma--glioma hybrid cells indicate that opiate dependence and associated tolerance develop within neurones bearing specific opiate receptors (opiate-sensitive neurones). The essential change appears to be an hypertrophy of the cyclic AMP system, in response to inhibition by opiate of a neuronal adenylate cyclase.
MeSH terms
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Action Potentials
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Animals
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Brain / drug effects*
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Cells, Cultured
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Cyclic AMP / metabolism
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Drug Tolerance
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Guinea Pigs
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Humans
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Hybrid Cells / drug effects
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Ileum / innervation
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In Vitro Techniques
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Myenteric Plexus / drug effects*
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Naloxone / pharmacology
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Opioid-Related Disorders*
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Receptors, Opioid / drug effects*
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Substance Withdrawal Syndrome / physiopathology
Substances
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Receptors, Opioid
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Naloxone
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Cyclic AMP