Receptor for ATP in the membrane of mammalian sensory neurones

Neurosci Lett. 1983 Jan 31;35(1):41-5. doi: 10.1016/0304-3940(83)90524-4.

Abstract

ATP-activated conductance has been found in a large number of neurones isolated from various sensory ganglia of the rat and cat. The inward current produced by ATP (Kd = 5 x 10(-6) M) is carried by cations and demonstrates rapid activation and slow desensitization. The sequence of agonists (ATP greater than ADP with AMP and adenosine ineffective) is different from those previously described for purinergic receptors P1 and P2.

MeSH terms

  • Adenosine Triphosphate / pharmacology
  • Adenosine Triphosphate / physiology
  • Animals
  • Cations, Divalent / metabolism
  • Cats
  • Cell Membrane / analysis
  • Cell Membrane Permeability
  • Dose-Response Relationship, Drug
  • Electric Conductivity
  • Ion Exchange
  • Neurons, Afferent / analysis*
  • Neurons, Afferent / physiology
  • Rats
  • Receptors, Cell Surface / analysis*
  • Receptors, Cell Surface / physiology
  • Receptors, Purinergic

Substances

  • Cations, Divalent
  • Receptors, Cell Surface
  • Receptors, Purinergic
  • Adenosine Triphosphate