Abstract
This paper reports the presence of a Na+-uptake component in rat brain synaptosomes that is coupled to H+-efflux as monitored from the acidification of the extrasynaptosomal space. This exchange mechanism is inhibited by amiloride and two of its more potent derivatives: dimethylamiloride and ethylisopropylamiloride.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acid-Base Equilibrium / drug effects*
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Amiloride / pharmacology*
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Animals
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Brain / drug effects*
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Culture Techniques
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Ion Channels / drug effects*
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Kinetics
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Pyrazines / pharmacology*
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Rats
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Sodium / metabolism*
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Synaptosomes / drug effects*
Substances
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Ion Channels
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Pyrazines
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Amiloride
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Sodium