A new model for embryotoxicity testing: teratogenicity and pharmacokinetics of valproic acid following constant-rate administration in the mouse using human therapeutic drug and metabolite concentrations

Life Sci. 1981 Dec 28;29(26):2803-14. doi: 10.1016/0024-3205(81)90541-5.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Blood Proteins / metabolism
  • Disease Models, Animal
  • Drug Evaluation, Preclinical / methods
  • Female
  • Fetus / drug effects
  • Half-Life
  • Humans
  • Kinetics
  • Mice
  • Pregnancy
  • Teratogens*
  • Valproic Acid / metabolism
  • Valproic Acid / therapeutic use
  • Valproic Acid / toxicity*

Substances

  • Blood Proteins
  • Teratogens
  • Valproic Acid