Abstract
Feeding rats with a diet containing 0.25% clofibrate for 2 weeks elevated the hepatic NAD+ and total nicotinate levels significantly. Other peroxisome proliferators, such as 2-(4-chlorophenoxy)propionic acid and di(2-ethylhexyl)phthalate, had similar effects. When rats were fed the control diet without clofibrate for 1 week after 2 weeks of the clofibrate diet, the hepatic NAD+ level returned to the control value. Muscular NAD+ content was not affected by the peroxisome proliferators. The results were discussed in relation to induction of peroxisomal beta-oxidation enzymes by the peroxisome proliferators.
MeSH terms
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Animals
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Clofibrate / administration & dosage*
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Clofibrate / pharmacology
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Diet*
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Diethylhexyl Phthalate / administration & dosage
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Diethylhexyl Phthalate / pharmacology
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Fenofibrate / administration & dosage
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Fenofibrate / analogs & derivatives
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Fenofibrate / pharmacology
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Hypolipidemic Agents / administration & dosage*
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Hypolipidemic Agents / pharmacology
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Liver / drug effects
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Liver / metabolism*
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Liver / ultrastructure
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Male
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Microbodies / drug effects
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Microbodies / metabolism
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NAD / metabolism*
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Rats
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Rats, Sprague-Dawley
Substances
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Hypolipidemic Agents
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NAD
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fenofibric acid
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Diethylhexyl Phthalate
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Clofibrate
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Fenofibrate