Abstract
The past two years have seen significant advances in our understanding of IL-2 gene transcription. Many of the relevant transcription factors have been identified, the intracellular mechanisms regulating their functions are being elucidated, and the multiple roles of calcineurin are beginning to be appreciated.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Base Sequence
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Calcineurin
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Calmodulin-Binding Proteins / genetics
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Calmodulin-Binding Proteins / metabolism
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DNA-Binding Proteins / genetics
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Gene Expression
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Humans
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Interleukin-2 / biosynthesis
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Interleukin-2 / genetics*
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Molecular Sequence Data
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Mutation
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NF-kappa B / genetics
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NFATC Transcription Factors
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Nuclear Proteins / genetics
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Phosphoprotein Phosphatases / genetics
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Phosphoprotein Phosphatases / metabolism
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Phosphoproteins / genetics
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RNA, Messenger / biosynthesis
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RNA, Messenger / genetics
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Regulatory Sequences, Nucleic Acid
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Signal Transduction
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Transcription Factor AP-1 / biosynthesis
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Transcription Factor AP-1 / genetics
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Transcription Factors / genetics
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Transcription, Genetic*
Substances
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Calmodulin-Binding Proteins
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DNA-Binding Proteins
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Interleukin-2
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NF-kappa B
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NFATC Transcription Factors
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Nuclear Proteins
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Phosphoproteins
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RNA, Messenger
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Transcription Factor AP-1
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Transcription Factors
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Calcineurin
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Phosphoprotein Phosphatases