Poly(ADP-ribose) polymerase: structure-function relationship

M Masson; V Rolli; F Dantzer; C Trucco; V Schreiber; S Fribourg; M Molinete; A Ruf; E A Miranda; C Niedergang

doi:10.1016/0300-9084(96)88160-0

Poly(ADP-ribose) polymerase: structure-function relationship

Biochimie. 1995;77(6):456-61. doi: 10.1016/0300-9084(96)88160-0.

Authors

M Masson¹, V Rolli, F Dantzer, C Trucco, V Schreiber, S Fribourg, M Molinete, A Ruf, E A Miranda, C Niedergang, et al.

Affiliation

¹ Ecole Supérieure de Biotechnologie de Strasbourg, UPR 9003 du CNRS, Illkirch, France.

PMID: 7578429
DOI: 10.1016/0300-9084(96)88160-0

Abstract

Dissection of the human poly(ADP-ribose) polymerase (PARP) molecule in terms of its structure-function relationship has proved to be an essential step towards understanding the biological role of poly(ADP-ribosylation) as a cellular response to DNA damage in eukaryotes. Current approaches aimed at elucidating the implication of this multifunctional enzyme in the maintenance of the genomic integrity will be presented.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Catalysis
Chickens
Crystallization
Crystallography, X-Ray
DNA Damage
DNA Repair*
DNA-Binding Proteins / chemistry
DNA-Binding Proteins / physiology
Genome, Human
HeLa Cells
Humans
Poly(ADP-ribose) Polymerases / chemistry*
Poly(ADP-ribose) Polymerases / physiology*
Protein Structure, Tertiary
Recombinant Proteins / chemistry
Structure-Activity Relationship
Transfection

Substances

DNA-Binding Proteins
Recombinant Proteins
Poly(ADP-ribose) Polymerases