Abstract
In adult rat hippocampal slices, (2S,1'R,2'R,3'R)-2-(2,3-dicarboxycyclopropyl)glycine (DCG-IV) did not affect the basal hydrolysis of polyphosphoinositides but dramatically enhanced (EC50 value = 30 nM) the stimulation of [3H]inositol monophosphate (InsP) formation by quisqualate, without substantially affecting the stimulation produced by maximal concentrations of 1S,3R-amino-cyclopentane-1,3-dicarboxylic acid (ACPD) or carbamylcholine. alpha-Amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) was virtually devoid of activity on [3H]InsP formation, either in the absence or presence of DCG-IV. These results suggest that DCG-IV acts, directly or indirectly, as a positive modulator of metabotropic glutamate receptors in the rat hippocampus.
MeSH terms
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Animals
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Carbachol / pharmacology
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Cycloleucine / analogs & derivatives
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Cycloleucine / pharmacology
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Cyclopropanes / pharmacology*
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Glycine / analogs & derivatives*
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Glycine / pharmacology
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Hippocampus / drug effects
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Hippocampus / metabolism*
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Ibotenic Acid / analogs & derivatives
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Ibotenic Acid / pharmacology
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In Vitro Techniques
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Male
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Phosphatidylinositols / metabolism*
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Quisqualic Acid / pharmacology*
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Rats
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Rats, Sprague-Dawley
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Receptors, Glutamate / drug effects*
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Receptors, Glutamate / metabolism
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alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
Substances
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Cyclopropanes
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Phosphatidylinositols
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Receptors, Glutamate
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Cycloleucine
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1-amino-1,3-dicarboxycyclopentane
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2-(2,3-dicarboxycyclopropyl)glycine
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Ibotenic Acid
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alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
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Quisqualic Acid
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Carbachol
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Glycine