Abstract
The mechanisms of action of the immunosuppressive drugs cyclosporin A (CsA), FK506 and rapamycin are strikingly conserved from yeast to human T cells. Recent results obtained with yeast corroborate calcineurin as the target of CsA-cyclophilin and FK506-FKBP complexes, and reveal a phosphatidylinositol 3-kinase homologue as the target of the rapamycin-FKBP complex.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Amino Acid Isomerases / metabolism
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Amino Acid Sequence
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Calcineurin
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Calmodulin-Binding Proteins / metabolism
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Carrier Proteins / metabolism
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Consensus Sequence
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Cyclosporine / pharmacology*
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Immunosuppressive Agents / pharmacology*
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Molecular Sequence Data
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Peptidylprolyl Isomerase
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Phosphatidylinositol 3-Kinases
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Phosphoprotein Phosphatases / metabolism
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Phosphotransferases (Alcohol Group Acceptor) / metabolism
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Polyenes / pharmacology*
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Saccharomyces cerevisiae / drug effects
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Signal Transduction / drug effects
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Sirolimus
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Tacrolimus / pharmacology*
Substances
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Calmodulin-Binding Proteins
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Carrier Proteins
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Immunosuppressive Agents
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Polyenes
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Cyclosporine
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Phosphotransferases (Alcohol Group Acceptor)
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Calcineurin
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Phosphoprotein Phosphatases
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Amino Acid Isomerases
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Peptidylprolyl Isomerase
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Sirolimus
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Tacrolimus