Abstract
Recent structural and mechanistic studies, as well as the discovery of new enzymes in the DNA topoisomerase family, allow these enzymes to be classified into three groups. Each group reflects the evolution of three different mechanistic strategies to manipulate DNA topology.
MeSH terms
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Animals
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Binding Sites
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DNA / chemistry
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DNA / metabolism
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DNA Topoisomerases, Type I / chemistry
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DNA Topoisomerases, Type I / classification
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DNA Topoisomerases, Type I / metabolism*
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DNA Topoisomerases, Type II / metabolism
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Humans
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Models, Molecular
Substances
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DNA
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DNA Topoisomerases, Type I
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DNA Topoisomerases, Type II