The mechanisms of DNA topoisomerases

J Roca

doi:10.1016/s0968-0004(00)88993-8

The mechanisms of DNA topoisomerases

Trends Biochem Sci. 1995 Apr;20(4):156-60. doi: 10.1016/s0968-0004(00)88993-8.

Author

J Roca¹

Affiliation

¹ Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.

PMID: 7770916
DOI: 10.1016/s0968-0004(00)88993-8

Abstract

Recent structural and mechanistic studies, as well as the discovery of new enzymes in the DNA topoisomerase family, allow these enzymes to be classified into three groups. Each group reflects the evolution of three different mechanistic strategies to manipulate DNA topology.

Publication types

Review

MeSH terms

Animals
Binding Sites
DNA / chemistry
DNA / metabolism
DNA Topoisomerases, Type I / chemistry
DNA Topoisomerases, Type I / classification
DNA Topoisomerases, Type I / metabolism*
DNA Topoisomerases, Type II / metabolism
Humans
Models, Molecular

Substances

DNA
DNA Topoisomerases, Type I
DNA Topoisomerases, Type II