Abstract
Mobilization of Ca+2 from intracellular stores is a signalling mechanism that is of fundamental importance to many cellular processes. It is mediated by two major mechanisms, the inositol 1,4,5-trisphosphate pathway and the Ca+2-induced Ca+2 release process. A naturally occurring metabolite of NAD+ called cyclic ADP-ribose has been discovered recently and shown to be as effective as inositol 1,4,5-trisphosphate in mobilizing Ca+2 stores in sea urchin eggs, a marine invertebrate cell, as well as several mammalian cells. This article reviews the accumulating evidence that indicates cyclic ADP-ribose may function as a physiological regulator of the Ca+2-induced Ca+2 release process and the current knowledge about its receptor as well as the enzymes involved in its metabolism.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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ADP-ribosyl Cyclase
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ADP-ribosyl Cyclase 1
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Adenosine Diphosphate Ribose / analogs & derivatives*
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Adenosine Diphosphate Ribose / antagonists & inhibitors
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Adenosine Diphosphate Ribose / physiology
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Animals
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Antigens, CD*
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Antigens, Differentiation / metabolism
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Calcium / metabolism*
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Cyclic ADP-Ribose
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Humans
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Membrane Glycoproteins
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Molecular Structure
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N-Glycosyl Hydrolases / metabolism
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NAD / metabolism*
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Receptors, Cell Surface / metabolism
Substances
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Antigens, CD
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Antigens, Differentiation
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Membrane Glycoproteins
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Receptors, Cell Surface
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cyclic ADP-ribose receptor
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NAD
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Cyclic ADP-Ribose
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Adenosine Diphosphate Ribose
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N-Glycosyl Hydrolases
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ADP-ribosyl Cyclase
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CD38 protein, human
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ADP-ribosyl Cyclase 1
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Calcium