Abstract
Hepatocyte nuclear factor 4 (HNF-4) is a key transcription factor involved in the specific expression of many genes in liver and intestine. Sequences of cDNAs coding for HNF-4 have been established in rat and Drosophila melanogaster. Rat HNF-4 exhibits two isoforms which probably result from differential splicing. We have isolated HNF-4 cDNAs from an adult human cDNA library. Sequence analysis revealed that two HNF-4 isoforms are also present in human liver. The complete sequence of the longest human isoform has been established and compared to the rat HNF-4 amino-acid sequences.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Amino Acid Sequence
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Animals
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Base Sequence
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Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
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Cloning, Molecular
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DNA, Complementary
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DNA-Binding Proteins*
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Drosophila melanogaster / genetics
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Hepatocyte Nuclear Factor 4
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Humans
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Liver / metabolism*
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Molecular Sequence Data
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Phosphoproteins*
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Rats
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Sequence Homology, Amino Acid
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Transcription Factors / genetics*
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Tumor Cells, Cultured
Substances
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Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
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DNA, Complementary
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DNA-Binding Proteins
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Hepatocyte Nuclear Factor 4
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MLX protein, human
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Phosphoproteins
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Transcription Factors