Poly(ADP-ribose) polymerase: a molecular nick-sensor

G de Murcia; J Ménissier de Murcia

doi:10.1016/0968-0004(94)90280-1

Poly(ADP-ribose) polymerase: a molecular nick-sensor

Trends Biochem Sci. 1994 Apr;19(4):172-6. doi: 10.1016/0968-0004(94)90280-1.

Authors

G de Murcia¹, J Ménissier de Murcia

Affiliation

¹ Institut de Biologie Moléculaire et Cellulaire du Centre National de la Recherche Scientifique, Unité de Cancérogénèse et Mutagénèse Moléculaire et Structurale, Strasbourg, France.

PMID: 8016868
DOI: 10.1016/0968-0004(94)90280-1

Abstract

Poly(ADP-ribose) polymerase (PARP) participates in the intricate network of systems developed by the eukaryotic cell to cope with the numerous environmental and endogenous genotoxic agents. Cloning of the PARP gene has allowed the development of genetic and molecular approaches to elucidate the structure and function of this abundant and highly conserved enzyme.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Humans
Poly Adenosine Diphosphate Ribose / biosynthesis
Poly(ADP-ribose) Polymerases* / chemistry
Poly(ADP-ribose) Polymerases* / genetics
Poly(ADP-ribose) Polymerases* / metabolism
Repetitive Sequences, Nucleic Acid

Substances

Poly Adenosine Diphosphate Ribose
Poly(ADP-ribose) Polymerases