Staurosporine derivatives reverse multidrug resistance without correlation with their protein kinase inhibitory activities

J Antibiot (Tokyo). 1993 Feb;46(2):353-5. doi: 10.7164/antibiotics.46.353.

Authors

S Wakusawa¹, K Inoko, K Miyamoto, S Kajita, T Hasegawa, K Harimaya, M Koyama

Affiliation

¹ Research Laboratory for Development of Medicine, School of Pharmacy, Hokuriku University, Kanazawa, Japan.

PMID: 8096836
DOI: 10.7164/antibiotics.46.353

No abstract available

MeSH terms

ATP Binding Cassette Transporter, Subfamily B, Member 1
Alkaloids / pharmacology*
Animals
Drug Resistance*
Leukemia P388 / metabolism
Leukemia P388 / pathology
Membrane Glycoproteins / metabolism
Mice
Protein Kinase C / antagonists & inhibitors*
Protein Kinase Inhibitors*
Staurosporine
Structure-Activity Relationship
Tumor Cells, Cultured / drug effects

Substances

ATP Binding Cassette Transporter, Subfamily B, Member 1
Alkaloids
Membrane Glycoproteins
Protein Kinase Inhibitors
Protein Kinase C
Staurosporine