Abstract
The mouse Unp gene is related to TRE17, a human oncogene, but is not its mouse homolog. Unp is a ubiquitously expressed gene producing two related mRNAs. The protein product of Unp is localized in the nucleus. Expression of Unp from a highly active promoter results in tumorigenic transformation of NIH3T3 cells injected into athymic mice. Unp therefore encodes a novel nuclear oncoprotein.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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3T3 Cells
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Amino Acid Sequence
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Animals
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Mice
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Mice, Nude
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Molecular Sequence Data
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Nuclear Proteins / genetics*
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Oncogene Proteins / chemistry
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Oncogene Proteins / genetics*
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Proto-Oncogene Mas
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Proto-Oncogene Proteins
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Proto-Oncogenes*
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Ubiquitin Thiolesterase
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Ubiquitin-Specific Proteases
Substances
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MAS1 protein, human
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Nuclear Proteins
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Oncogene Proteins
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Proto-Oncogene Mas
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Proto-Oncogene Proteins
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Usp4 protein, mouse
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Ubiquitin Thiolesterase
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Ubiquitin-Specific Proteases