Inositol trisphosphate and calcium signalling

Nature. 1993 Jan 28;361(6410):315-25. doi: 10.1038/361315a0.

Abstract

Inositol trisphosphate is a second messenger that controls many cellular processes by generating internal calcium signals. It operates through receptors whose molecular and physiological properties closely resemble the calcium-mobilizing ryanodine receptors of muscle. This family of intracellular calcium channels displays the regenerative process of calcium-induced calcium release responsible for the complex spatiotemporal patterns of calcium waves and oscillations. Such a dynamic signalling pathway controls many cellular processes, including fertilization, cell growth, transformation, secretion, smooth muscle contraction, sensory perception and neuronal signalling.

Publication types

  • Review

MeSH terms

  • Animals
  • Calcium / metabolism
  • Calcium / physiology*
  • Calcium Channels*
  • Cell Cycle
  • Cell Division
  • Cell Transformation, Neoplastic
  • Female
  • Fertilization
  • GTP-Binding Proteins / physiology
  • Inositol 1,4,5-Trisphosphate / metabolism
  • Inositol 1,4,5-Trisphosphate / physiology*
  • Inositol 1,4,5-Trisphosphate Receptors
  • Male
  • Models, Biological
  • Neuronal Plasticity
  • Protein-Tyrosine Kinases / metabolism
  • Receptors, Cell Surface / physiology
  • Receptors, Cholinergic / physiology
  • Receptors, Cytoplasmic and Nuclear*
  • Ryanodine / pharmacology
  • Ryanodine Receptor Calcium Release Channel
  • Second Messenger Systems*
  • Signal Transduction*
  • Synapses / physiology

Substances

  • Calcium Channels
  • Inositol 1,4,5-Trisphosphate Receptors
  • Receptors, Cell Surface
  • Receptors, Cholinergic
  • Receptors, Cytoplasmic and Nuclear
  • Ryanodine Receptor Calcium Release Channel
  • Ryanodine
  • Inositol 1,4,5-Trisphosphate
  • Protein-Tyrosine Kinases
  • GTP-Binding Proteins
  • Calcium