A selective delta 1 opioid receptor agonist derived from oxymorphone. Evidence for separate recognition sites for delta 1 opioid receptor agonists and antagonists

J Med Chem. 1993 Aug 20;36(17):2572-4. doi: 10.1021/jm00069a017.

Authors

P S Portoghese¹, S T Moe, A E Takemori

Affiliation

¹ Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, Minneapolis 55455.

PMID: 8394935
DOI: 10.1021/jm00069a017

No abstract available

Publication types

Research Support, U.S. Gov't, P.H.S.

MeSH terms

Animals
Brain / metabolism
Dose-Response Relationship, Drug
Guinea Pigs
Male
Mice
Muscle, Smooth / drug effects
Oxymorphone / analogs & derivatives*
Oxymorphone / metabolism
Oxymorphone / pharmacology
Receptors, Opioid, delta / antagonists & inhibitors
Receptors, Opioid, delta / drug effects*
Spiro Compounds / metabolism
Spiro Compounds / pharmacology*
Stereoisomerism
Structure-Activity Relationship
Vas Deferens / drug effects

Substances

Receptors, Opioid, delta
Spiro Compounds
7-spiroindanyloxymorphone
Oxymorphone