Abstract
Myristica seed extr. administration to hypercholesterolemic rabbits reduced serum cholesterol and LDL Cholesterol by 69.1% and 76.3% respectively and also lowered cholesterol/phospholipid ratio by 31.2% and elevated the decreased HDL-ratio significantly. Myristica seed extr. feeding also prevented the accumulation of cholesterol, phospholipids and triglycerides in liver, heart and aorta and dissolved atheromatous plaques of aorta by 70.9-76.5%. Fecal excretion of cholesterol and phospholipid were significantly increased in seed extract fed rabbits.
MeSH terms
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Animals
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Anticholesteremic Agents / therapeutic use*
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Aorta / metabolism
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Aorta / pathology
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Arteriosclerosis / prevention & control*
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Cholesterol, HDL / blood
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Diet
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Feces / chemistry
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Hypercholesterolemia / pathology
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Hypercholesterolemia / prevention & control*
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India
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Lipid Metabolism
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Lipids / blood
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Liver / drug effects
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Liver / metabolism
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Male
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Myocardium / metabolism
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Phospholipids / blood
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Plant Extracts / therapeutic use
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Plants, Medicinal / chemistry*
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Rabbits
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Seeds / chemistry
Substances
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Anticholesteremic Agents
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Cholesterol, HDL
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Lipids
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Phospholipids
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Plant Extracts