Abstract
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is an exogenous ligand for the cytosolic aryl hydrocarbon receptor (AhR), a ligand-inducible transcription factor whose exact physiological role remains elusive. TCDD has been shown to modulate the expression of a large array of genes, albeit often indirectly, by demonstration of protein or mRNA upregulation. Here, by computer analysis of available promoter sequences, we identify dioxin-responsive elements in the promoter regions of many putative AhR regulated and therefore dioxin-inducible genes.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Base Sequence
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Consensus Sequence / genetics
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Cytokines / genetics
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Databases, Factual
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Down-Regulation
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Gene Expression Regulation / genetics*
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Humans
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MEDLINE
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Mice
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Molecular Sequence Data
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Polychlorinated Dibenzodioxins / metabolism*
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Polychlorinated Dibenzodioxins / pharmacology
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Promoter Regions, Genetic*
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Protein Biosynthesis
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RNA, Messenger / biosynthesis
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Rats
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Receptors, Aryl Hydrocarbon / metabolism
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Up-Regulation
Substances
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Cytokines
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Polychlorinated Dibenzodioxins
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RNA, Messenger
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Receptors, Aryl Hydrocarbon