Abstract
A major component of ethyl acetate (EtOAc) and chloroform (CHCl3) fractions of Ventilago leiocarpa Bunge (Rhamnaceae), emodin, was isolated and exhibited hepatoprotective effects on carbon tetrachloride (CCl4) as well as D-galactosamine (D-GalN)-induced liver damage. The histopathological examination also clearly showed that emodin reduced lymphocyte cells, Kupffer cells, ballooning degeneration, cell necrosis and hyaline degeneration on CCl4 and D-galactosamine-induced tests.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetates / chemistry
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Analysis of Variance
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Animals
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Carbon Tetrachloride / toxicity*
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Chemical Fractionation
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Chloroform / chemistry
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Emodin / isolation & purification
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Emodin / metabolism
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Emodin / pharmacology*
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Emodin / therapeutic use
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Enzyme Inhibitors / isolation & purification
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Enzyme Inhibitors / metabolism
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Enzyme Inhibitors / pharmacology*
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Enzyme Inhibitors / therapeutic use
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Galactosamine / toxicity*
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Hyalin / metabolism
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Kupffer Cells / cytology
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Kupffer Cells / drug effects
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Kupffer Cells / pathology
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Liver / drug effects*
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Liver / metabolism
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Liver / pathology
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Lymphocytes / cytology
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Lymphocytes / drug effects
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Lymphocytes / pathology
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Male
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Necrosis
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Plant Extracts / isolation & purification
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Plant Extracts / metabolism
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Plant Extracts / pharmacology
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Rats
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Rats, Wistar
Substances
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Acetates
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Enzyme Inhibitors
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Plant Extracts
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Galactosamine
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ethyl acetate
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Chloroform
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Carbon Tetrachloride
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Emodin