Knockout mice and dirty drugs. Drug addiction

Curr Biol. 1996 Aug 1;6(8):935-6. doi: 10.1016/s0960-9822(02)00630-9.

Abstract

Recent studies with knockout mice implicate the dopamine transporter as the target of the locomotor effects of the addictive psychomotor drugs cocaine and amphetamine; studies of reward in these animals are eagerly awaited.

Publication types

  • Review

MeSH terms

  • Amphetamine / pharmacology*
  • Animals
  • Carrier Proteins / drug effects*
  • Carrier Proteins / genetics
  • Carrier Proteins / metabolism
  • Cocaine / pharmacology*
  • Dopamine / metabolism
  • Dopamine Plasma Membrane Transport Proteins
  • Locomotion / drug effects
  • Membrane Glycoproteins*
  • Membrane Transport Proteins*
  • Mice
  • Mice, Knockout
  • Nerve Tissue Proteins*
  • Opioid-Related Disorders / genetics*
  • Opioid-Related Disorders / metabolism

Substances

  • Carrier Proteins
  • Dopamine Plasma Membrane Transport Proteins
  • Membrane Glycoproteins
  • Membrane Transport Proteins
  • Nerve Tissue Proteins
  • Amphetamine
  • Cocaine
  • Dopamine