Abstract
Interferon-gamma (IFN-gamma), also known as type II interferon, is an important immunoregulatory gene that has multiple effects on the development, maturation, and function of the immune system. IFN-gamma mRNA and protein are expressed predominantly by T cells and large granular lymphocytes. The IFN-gamma mRNA is induced/inhibited in these cell types by a wide variety of extracellular signals, thus implicating a number of diverse, yet convergent signal transduction pathways in its transcriptional control. In this review, I describe how DNA methylation and specific DNA binding proteins may regulate transcription of the IFN-gamma gene in response to extracellular signals.
MeSH terms
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Animals
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Cyclosporine / pharmacology
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DNA / chemistry
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DNA / genetics
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DNA-Binding Proteins / physiology
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Enhancer Elements, Genetic
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Erythroid-Specific DNA-Binding Factors
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Gene Expression Regulation* / drug effects
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Glucocorticoids / pharmacology
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Humans
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Interferon-gamma / biosynthesis
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Interferon-gamma / genetics*
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Ionomycin / pharmacology
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Leukemia-Lymphoma, Adult T-Cell / pathology
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Lymphocyte Activation
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Lymphocyte Subsets / drug effects
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Lymphocyte Subsets / metabolism*
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Methylation
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Mice
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NF-kappa B / physiology
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Phytohemagglutinins / pharmacology
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Promoter Regions, Genetic / drug effects
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RNA, Messenger / biosynthesis
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RNA, Messenger / genetics
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Signal Transduction / drug effects
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Signal Transduction / physiology
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T-Lymphocytes / metabolism
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Tetradecanoylphorbol Acetate / pharmacology
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Transcription Factors / physiology
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Transcription, Genetic
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Tumor Cells, Cultured
Substances
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DNA-Binding Proteins
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Erythroid-Specific DNA-Binding Factors
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Glucocorticoids
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NF-kappa B
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Phytohemagglutinins
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RNA, Messenger
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Transcription Factors
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Ionomycin
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Interferon-gamma
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Cyclosporine
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DNA
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Tetradecanoylphorbol Acetate