Abstract
Abortive attempts at DNA repair can contribute to the effects of DNA damage inflicted by cytotoxic drugs. DNA methylation damage, 6-thioguanine and cisplatin adducts all owe their cytotoxicity in part to the intervention of DNA mismatch repair.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Antineoplastic Agents / pharmacology*
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Cisplatin / pharmacology
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DNA Methylation*
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DNA Repair
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Humans
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Mercaptopurine / pharmacology
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Thioguanine / pharmacology
Substances
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Antineoplastic Agents
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Mercaptopurine
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Thioguanine
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Cisplatin