Inhibition of neuronal activity in rat hippocampal slices by Aconitum alkaloids

Brain Res. 1996 Oct 28;738(1):154-7. doi: 10.1016/0006-8993(96)00990-0.

Abstract

The structurally related Aconitum alkaloids aconitine, lappaconitine, and 6-benzoylheteratisine inhibited the orthodromic and antidromic population spike in hippocampal CA1 area in a frequency-dependent manner. Aconitine (1 microM) completely suppressed epileptiform activity induced by omission of Mg2+ as well as normal neuronal activity, whereas lappaconitine (10 microM) and 6-benzoylheteratisine (10 microM) diminished epileptiform activity by sparing normal neuronal activity.

MeSH terms

  • Aconitine / analogs & derivatives*
  • Aconitine / pharmacology*
  • Action Potentials / drug effects
  • Alkaloids / pharmacology*
  • Animals
  • Electric Stimulation
  • Electrophysiology
  • Epilepsy / physiopathology
  • Hippocampus / cytology
  • Hippocampus / drug effects*
  • Hippocampus / physiology*
  • In Vitro Techniques
  • Magnesium / metabolism
  • Neural Inhibition*
  • Neurons / drug effects*
  • Neurons / physiology*
  • Rats

Substances

  • Alkaloids
  • 6-benzoylheteratisine
  • Magnesium
  • Aconitine
  • lappaconitine