Abstract
The molecules that form signaling complexes with the cytoplasmic domains of tumor necrosis factor (TNF) receptors (TNF-Rs) and CD95 have been identified recently. The death-signaling pathways induced by TNF-R1 and CD95 involve a group of death domain containing proteins, including caspase-8, a member of the interleukin-1beta-converting enzyme family. TNF-R1 and TNF-R2 also interact with the members of both the TNF-R associated factor family and the inhibitor of apoptosis protein family; these interactions lead to cell survival.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Apoptosis / physiology*
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Cell Survival / physiology
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Fas Ligand Protein
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Humans
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Membrane Glycoproteins / metabolism*
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Receptors, Tumor Necrosis Factor / metabolism*
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Signal Transduction*
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Tumor Necrosis Factor-alpha / metabolism*
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fas Receptor / metabolism*
Substances
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FASLG protein, human
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Fas Ligand Protein
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Membrane Glycoproteins
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Receptors, Tumor Necrosis Factor
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Tumor Necrosis Factor-alpha
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fas Receptor