Inhibitory effects of talipexole and pramipexole on MPTP-induced dopamine reduction in the striatum of C57BL/6N mice

Jpn J Pharmacol. 1997 May;74(1):51-7. doi: 10.1254/jjp.74.51.

Abstract

We have investigated the effects of two novel antiparkinsonian drugs, talipexole (Domin) and pramipexole, on MPTP-induced dopamine (DA) reduction in the striatum of C57BL/6N mice in comparison with those of bromocriptine. Fifteen days after MPTP treatment (25 mg/kg, i.p., given daily for 5 days), the DA content in the striatum was decreased to 40-60% of the control value. Among the three dopamine receptor agonists, talipexole and pramipexole (1 mg/kg, i.p., once a day for 20 days) more significantly suppressed the MPTP-induced DA reduction in the striatum than bromocriptine (10 mg/kg, i.p., once a day for 20 days). Talipexole did not influence [3H]MPP+ uptake into striatal synaptosomes. These results suggest that talipexole and pramipexole have a protective effect against MPTP-induced DA reduction in the striatum of C57BL/6N mice.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / administration & dosage
  • 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / antagonists & inhibitors*
  • 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / pharmacology
  • 1-Methyl-4-phenylpyridinium / pharmacology
  • 3,4-Dihydroxyphenylacetic Acid / metabolism
  • Animals
  • Azepines / administration & dosage
  • Azepines / pharmacology*
  • Benzothiazoles
  • Bromocriptine / pharmacology
  • Dopamine / metabolism*
  • Dopamine Agents / administration & dosage
  • Dopamine Agents / pharmacology*
  • Dopamine Agonists / administration & dosage
  • Dopamine Agonists / pharmacology*
  • Homovanillic Acid / metabolism
  • In Vitro Techniques
  • Injections, Intraperitoneal
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Neostriatum / drug effects
  • Neostriatum / metabolism*
  • Pramipexole
  • Synaptosomes / drug effects
  • Synaptosomes / metabolism
  • Thiazoles / administration & dosage
  • Thiazoles / pharmacology*

Substances

  • Azepines
  • Benzothiazoles
  • Dopamine Agents
  • Dopamine Agonists
  • Thiazoles
  • 3,4-Dihydroxyphenylacetic Acid
  • Bromocriptine
  • talipexole
  • Pramipexole
  • 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
  • 1-Methyl-4-phenylpyridinium
  • Dopamine
  • Homovanillic Acid