Abstract
We have investigated the effects of two novel antiparkinsonian drugs, talipexole (Domin) and pramipexole, on MPTP-induced dopamine (DA) reduction in the striatum of C57BL/6N mice in comparison with those of bromocriptine. Fifteen days after MPTP treatment (25 mg/kg, i.p., given daily for 5 days), the DA content in the striatum was decreased to 40-60% of the control value. Among the three dopamine receptor agonists, talipexole and pramipexole (1 mg/kg, i.p., once a day for 20 days) more significantly suppressed the MPTP-induced DA reduction in the striatum than bromocriptine (10 mg/kg, i.p., once a day for 20 days). Talipexole did not influence [3H]MPP+ uptake into striatal synaptosomes. These results suggest that talipexole and pramipexole have a protective effect against MPTP-induced DA reduction in the striatum of C57BL/6N mice.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / administration & dosage
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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / antagonists & inhibitors*
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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / pharmacology
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1-Methyl-4-phenylpyridinium / pharmacology
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3,4-Dihydroxyphenylacetic Acid / metabolism
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Animals
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Azepines / administration & dosage
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Azepines / pharmacology*
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Benzothiazoles
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Bromocriptine / pharmacology
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Dopamine / metabolism*
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Dopamine Agents / administration & dosage
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Dopamine Agents / pharmacology*
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Dopamine Agonists / administration & dosage
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Dopamine Agonists / pharmacology*
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Homovanillic Acid / metabolism
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In Vitro Techniques
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Injections, Intraperitoneal
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Male
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Mice
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Mice, Inbred C57BL
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Neostriatum / drug effects
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Neostriatum / metabolism*
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Pramipexole
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Synaptosomes / drug effects
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Synaptosomes / metabolism
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Thiazoles / administration & dosage
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Thiazoles / pharmacology*
Substances
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Azepines
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Benzothiazoles
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Dopamine Agents
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Dopamine Agonists
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Thiazoles
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3,4-Dihydroxyphenylacetic Acid
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Bromocriptine
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talipexole
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Pramipexole
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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
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1-Methyl-4-phenylpyridinium
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Dopamine
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Homovanillic Acid