Abstract
The process of apoptosis is used to eliminate unwanted cells from a wide variety of organisms. Various extracellular signals, often converging in common intracellular pathways, can induce apoptosis in a cell-type-specific fashion. Recent work from several laboratories has demonstrated that Rel/NF-kappa B transcription factors regulate apoptosis in many cell types. In most cells, Rel/NF-kappa B transcription factors appear to mediate survival signals that protect cells from apoptosis; however, under some circumstances, activation of these factors may also promote apoptosis.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Apoptosis / genetics*
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B-Lymphocytes
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CD40 Antigens
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Cell Survival
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Genes, Regulator
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Humans
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Ligands
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Lymphoma, B-Cell
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NF-kappa B / genetics*
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Oncogenes / genetics*
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Proto-Oncogene Proteins
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Proto-Oncogene Proteins c-bcl-2
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Transcription Factor RelB
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Transcription Factors
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Transforming Growth Factor beta
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Tumor Necrosis Factor-alpha
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bcl-X Protein
Substances
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BCL2L1 protein, human
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CD40 Antigens
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Ligands
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NF-kappa B
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Proto-Oncogene Proteins
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Proto-Oncogene Proteins c-bcl-2
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RELB protein, human
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Transcription Factors
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Transforming Growth Factor beta
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Tumor Necrosis Factor-alpha
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bcl-X Protein
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Transcription Factor RelB