C-terminal modifications of histidyl-N-benzylglycinamides to give improved inhibition of Ras farnesyltransferase, cellular activity, and anticancer activity in mice

J Med Chem. 1997 Oct 10;40(21):3319-22. doi: 10.1021/jm970470c.
No abstract available

MeSH terms

  • Alkyl and Aryl Transferases / antagonists & inhibitors*
  • Animals
  • Antineoplastic Agents / chemical synthesis*
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology
  • Cell Line
  • Dipeptides / chemical synthesis*
  • Dipeptides / chemistry
  • Dipeptides / pharmacology
  • Drug Screening Assays, Antitumor
  • Enzyme Inhibitors / chemical synthesis*
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / pharmacology
  • Mice
  • Molecular Structure
  • Neoplasms, Experimental / drug therapy
  • Protein Prenylation
  • Rats
  • Tumor Cells, Cultured
  • ras Proteins / metabolism*

Substances

  • Antineoplastic Agents
  • Dipeptides
  • Enzyme Inhibitors
  • PD 152440
  • benzyloxycarbonyl-histidyl-N-(2-(benzyloxyphenylmethyl))glycine N-(2-methyl-2-phenylpropyl)amide
  • Alkyl and Aryl Transferases
  • p21(ras) farnesyl-protein transferase
  • ras Proteins