Glucose transporter Glut 5 expression in microglial cells

Glia. 1997 Nov;21(3):327-31. doi: 10.1002/(sici)1098-1136(199711)21:3<327::aid-glia7>3.0.co;2-1.

Abstract

Glut 5 is a member of a family of facilitative glucose transporter proteins that are involved in the transportation of glucose and/or fructose across plasma membranes. Glut 5 is one of three isoforms expressed in brain. Using immunocytochemical and immunoblotting techniques in formalin fixed tissue, we have shown that Glut 5 is exclusively expressed in microglial cells of the human and rat brain. Our data demonstrate that unlike other microglial markers, Glut 5 can be used as a microglial marker in formalin fixed tissue.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Amino Acid Sequence
  • Animals
  • Brain / metabolism
  • Cells, Cultured
  • Child, Preschool
  • Glucose / metabolism*
  • Glucose Transporter Type 5
  • Humans
  • Microglia / cytology
  • Microglia / metabolism*
  • Middle Aged
  • Molecular Sequence Data
  • Monosaccharide Transport Proteins / biosynthesis*
  • Rats

Substances

  • Glucose Transporter Type 5
  • Monosaccharide Transport Proteins
  • Glucose